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Davies MJ, Bajaj HS, Broholm C, et al

Published in The Journal of Clinical Endocrinology & Metabolism , the study documents a short systemic half-life for the tetra-substituted GRF(129) sequence (~30 minutes), predictable dose proportionality and physiologic pulsatile GH release in response to a single SC dose

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In type 1 diabetic mice and high glucose-cultured HK-2 cells, it was demonstrated that circ_ASAP2 binding to miR-770-5p reduced inflammation and ferroptosis by regulating the SRY-box transcription factor 2 (SOX2)/SLC7A11 pathway[153]

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